Epigenetic modifications, such as acetylation, phosphorylation, methylation, ubiquitination,
and ADP ribosylation, of the highly conserved core histones, H2A, H2B, H3, and H4 …

Histone deacetylases (HDACs) are enzymes that modify key residues in histones to regulate
chromatin architecture, and they play a vital role in cell survival, cell-cycle progression, and …

During lytic infection, the genome of herpes simplex virus 1 (HSV-1) is associated with
limited levels of histones but does not form a regular repeating nucleosomal structure …

Recent studies have shown that histone code dictates the type and structure of chromatin.
Bearing in mind the importance of A-type lamins for chromatin arrangement, we studied the …

Human embryonic stem cells (hES) are unique in their pluripotency and capacity for self-
renewal. Therefore, we have studied the differences in the level of chromatin condensation …

Epigenetic histone (H3) modification patterns and the nuclear radial arrangement of select
genetic elements were compared in human embryonic stem cells (hESCs) before and after …

Malignant myeloblasts arising in high-risk myelodysplastic syndrome (MDS) and acute
myeloid leukemia (AML) are characterized by the constitutive activation of the anti-apoptotic …

We demonstrated that TNF-α suppressed differentiation and potentiated cell death induced
by butyrate (NaBt) in both adenocarcinoma HT-29 and fetal FHC human colon cells in vitro …

Nuclear locations of the c-myc gene and its transcripts (c-myc T) have been investigated in
relation to nuclear domains involved in RNA synthesis and processing. Transcription of the c …

Malignant breast cancer cells often exhibit lower expression and activity of manganese
superoxide dismutase (MnSOD) than their normal cell counterparts; however, the …