Once a rarely used subset of medical treatments, protein therapeutics have increased
dramatically in number and frequency of use since the introduction of the first recombinant …

TNF was originally described as a circulating factor that can cause necrosis of tumours, but
has since been identified as a key regulator of the inflammatory response. This review …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Guidelines and recommendations developed and/or endorsed by the American College of
Rheumatology (ACR) are intended to provide guidance for particular patterns of practice …

Background Interleukin 6 is involved in the pathogenesis of rheumatoid arthritis via its broad
effects on immune and inflammatory responses. Our aim was to assess the therapeutic …

This Review discusses physiological, emotional, behavioural, and cognitive aspects of
psychological adjustment to chronic illness. Reviewing the reports of the past decade, we …

Objective To examine the efficacy and safety of the humanized anti–interleukin‐6 receptor
antibody tocilizumab combined with conventional disease‐modifying antirheumatic drugs …

Introduction MicroRNAs are small noncoding RNA molecules that negatively regulate gene
expression via degradation or translational repression of their targeted mRNAs. It is known …

Objective Several microRNA, which are∼ 22‐nucleotide noncoding RNAs, exhibit tissue‐
specific or developmental stage–specific expression patterns and are associated with …

Objectives: This double-blind trial evaluated the efficacy and safety of abatacept or infliximab
vs placebo. The primary objective of this study was to evaluate the mean change from …