Fibroblast‐like synoviocytes (FLS) are resident mesenchymal cells of synovial joints that
have been recognized to play an increasingly important role in the pathogenesis of …

Chemotactic cytokines (chemokines) have been traditionally defined as small (10–14kDa)
secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are …

Primordial germ cell (PGC) migration in zebrafish is directed by the chemokine SDF-1a that
activates its receptor CXCR4b. Little is known about the molecular mechanisms controlling …

Various inflammatory diseases are characterized by tissue infiltration of neutrophils.
Chemokines recruit and activate leukocytes, but neutrophils are traditionally known to be …

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily
affects the small joints of the hands and feet. The inflammatory process is characterized by …

MicroRNAs (miRNAs or miRs) regulate diverse normal and abnormal cell functions. We
have identified a regulatory pathway in normal megakaryopoiesis, involving the PLZF …

Dysregulation of blood-brain barrier (BBB) function and transendothelial migration of
leukocytes are essential components of the development and propagation of active lesions …

Objective Interferon‐γ–inducible protein 10 (IP‐10; also called CXCL10), a chemokine
important in the migration and proliferation of T cells, is induced in a wide variety of cell …

Physiological interactions between the nervous and immune systems with components of
the local microenvironment are needed to maintain homeostasis throughout the body …

Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several
inflammatory conditions. However, it is unclear whether this interaction has a role in the …