A statistical change point model approach for the detection of DNA copy number variations in array CGH data

J Chen, YP Wang - IEEE/ACM Transactions on Computational …, 2008 - ieeexplore.ieee.org
Array comparative genomic hybridization (aCGH) provides a high-resolution and high-
throughput technique for screening of copy number variations (CNVs) within the entire …

[HTML][HTML] Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays

RB Scharpf, G Parmigiani, J Pevsner… - The annals of applied …, 2008 - ncbi.nlm.nih.gov
Chromosomal DNA is characterized by variation between individuals at the level of entire
chromosomes (eg aneuploidy in which the chromosome copy number is altered), segmental …

Stochastic segmentation models for array-based comparative genomic hybridization data analysis

TL Lai, H Xing, N Zhang - Biostatistics, 2008 - academic.oup.com
Array-based comparative genomic hybridization (array-CGH) is a high throughput, high
resolution technique for studying the genetics of cancer. Analysis of array-CGH data typically …

Model based approaches to array CGH data analysis

SP Shah - 2008 - open.library.ubc.ca
DNA copy number alterations (CNAs) are genetic changes that can produce adverse effects
in numerous human diseases, including cancer. CNAs are segments of DNA that have been …

[PDF][PDF] Centre for Statistical and Survey Methodology

RG Clark - 2008 - documents.uow.edu.au
Motivation: Existing methods for estimating copy number variations in array comparative
genomic hybridization (aCGH) data are limited to estimations of the gain/loss of …