Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …

Pituitary tumors are among the most common neoplasms in man; they account for
approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus …

Abstract The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-
terminal transcriptional activation domain, required for its cellular function. In the present …

Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia
type 1. We show that menin is essential for canonical Wnt/β-catenin signaling in cultured …

Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer
syndrome characterized primarily by tumors of the parathyroid glands (95% of cases) …

Multiple endocrine neoplasia type 1 (MEN1) and type 2 (MEN2) are rare autosomal-
dominant disorders characterized by primary tumours in at least two different endocrine …

Transcriptional activation of human telomerase reverse transcriptase (hTERT) is critical for
telomerase expression, a major step for cellular immortality and carcinogenesis. Although …

Somatostatin is a potent inhibitor of gastrin secretion and gene expression. Menin is a 67-
kDa protein product of the multiple endocrine neoplasia type 1 (MEN1) gene that when …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome caused by
mutations in the MEN1 tumor suppressor gene. Loss of the functional second copy of the …

Mutations of the multiple endocrine neoplasia type 1 (MEN1) gene predispose patients to
MEN1 that affects mainly endocrine tissues, suggesting important physiological functions of …