Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

Cancer is one of the most devastating disorders in our lives. Higher rate of proliferation than
death of cells is one of the essential factors for development of cancer. The dynamicity of cell …

Rho/ROCK signaling and caveolin-1 (Cav1) are implicated in tumor cell migration and
metastasis; however, the underlying molecular mechanisms remain poorly defined. Cav1 …

Background Meta-analyses of trials of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors
or statins for cardiovascular disease prevention have failed to show any statistically …

• Introduction• The caveolins• Caveolin‐1 in cell physiology‐Caveolin‐1 distribution‐
Caveolin‐1 and internalization‐Caveolin‐1 and cholesterol‐Regulation of caveolin‐1 …

Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately
gained recognition as a stage-and tissue-specific tumor modulator in vivo. Patient studies …

Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane.
Caveolin-1 is an essential constituent of caveolae and as such acts as a regulator of …

Caveolin-1 was up-regulated in different drug-resistant cancer cell lines and was suggested
to confer drug resistance by different mechanisms. However, the relation of caveolin-1 …

Background Methotrexate is one of the earliest cytotoxic drugs used in cancer therapy, and
despite the isolation of multiple other folate antagonists, methotrexate maintains its …

We have utilized small interfering RNA (siRNA)-mediated depletion of the β-COP subunit of
COP-I to explore COP-I function in organellar compartmentalization and protein traffic …