Evidence indicates that central glial activation depends on nerve inputs from the site of injury
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …

The importance of glial cells in the generation and maintenance of neuropathic pain is
becoming widely accepted. We examined the role of glial-specific gap junctions in …

Study Design. The contralateral pain-related behavioral and immunohistochemical changes
after hemilateral spinal nerve injury in rats were investigated. Objectives. We evaluated the …

Increased sensitivity contralateral to an injury has been described in humans and in various
models of neuropathic pain in rats. The mechanism underlying contralateral hypersensitivity …

JUSTIFICATIVA E OBJETIVOS: A dor neuropática é causada por lesão ou inflamação do
sistema nervoso. É síndrome complexa, com mecanismos biológicos pouco esclarecidos …

Patients with peripheral arterial disease (PAD) commonly suffer from ischemic pain
associated with severe thrombosis. However, the pathophysiology of peripheral ischemic …

JUSTIFICATIVA E OBJETIVOS: A dor neuropática é causada por lesão ou inflamação do
sistema nervoso. É síndrome complexa, com mecanismos biológicos pouco esclarecidos …

In order to imitate the in vivo situation with constituents from the blood–brain barrier,
astrocytes from newborn rat cerebral cortex were co-cultured with adult rat brain …

Os objetivos da presente tese de doutorado foram os de investigar o papel dos derivados
da guanina na nocicepção e compreender os mecanismos responsáveis pelos efeitos …

Life is full of physical pain. Normal pain is a life-sustaining protective mechanism and is not
a disease. Dysfunction of normal pain mechanisms can give rise to chronic pain. We are …