It is postulated that localized tissue oxidative stress is a key component in the development
of diabetic nephropathy. There remains controversy, however, as to whether this is an early …

Loss of redox homeostasis and formation of excessive free radicals play an important role in
the pathogenesis of kidney disease and hypertension. Free radicals such as reactive …

Coenzyme Q 10 (CoQ 10) plays a pivotal role in oxidative phosphorylation (OXPHOS) in that
it distributes electrons between the various dehydrogenases and the cytochrome segments …

To the Editor: Primary coenzyme Q10 deficiency is considered to be the only treatable
mitochondrial disorder, since patients have a response to oral coenzyme Q10 …

Abstract Coenzyme Q 10 (CoQ 10) is essential for electron transport in the mitochondrial
respiratory chain and antioxidant defense. Last year, we reported the first mutations in CoQ …

Collapsing glomerulopathy is a proliferative disease defined by segmental or global
wrinkling of the glomerular basement membranes associated with podocyte proliferation …

Coenzyme Q (CoQ) is an essential electron carrier in the respiratory chain whose deficiency
has been implicated in a wide variety of human mitochondrial disease manifestations. Its …

Abstract Coenzyme Q [TeX:] _ {10}(CoQ [TeX:] _ {10} or ubiquinone) is a lipid-soluble
component of virtually all cell membranes and has multiple metabolic functions. A major …

Homozygous mice carrying kd (kidney disease) mutations in the gene encoding prenyl
diphosphate synthase subunit 2 (Pdss2 kd/kd) develop interstitial nephritis and eventually …

Mitochondrial diseases can present with signs in almost any organ. Well planned clinical
evaluation is the key to successful diagnostic work-up of mitochondrial diseases. An …