The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

many potentially proatherogenic effects of leptin have been described, hyperleptinemia may
contribute to atherogenesis in obese individuals. The observation that leptin-deficient ob/ob …

OBJECTIVE—We hypothesized that the induction of heme oxygenase (HO)-1 and increased
HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse …

OBJECTIVE—We hypothesized that simvastatin may reduce adiponectin levels and insulin
sensitivity in hypercholesterolemic patients. RESEARCH DESIGN AND METHODS—This …

Aims Cardiovascular disease and type 2 diabetes mellitus are associated with low plasma
concentration of adiponectin. The aim of this study was to investigate whether adiponectin …

OBJECTIVE—The purpose of this study was to determine whether an association exists
between adiponectin and plaque composition in human coronary arteries. RESEARCH …

Background Preeclampsia (PE) is a serious complication of pregnancy which is associated
with an increased future metabolic and cardiovascular risk for both mother and newborn …

Combined hyperlipidemia results from overproduction of hepatically synthesized
apolipoprotein B in very low-density lipoproteins in association with reduced lipoprotein …

Objective The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and
the presence of insulin resistance is recognized as the pathophysiological hallmark of this …

Adipocyte cytokines regulate glucose metabolism and insulin resistance and adiponectin is
thought to have a protective effect against atherosclerosis. Studies have shown that …