Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
GP Anderson - The Lancet, 2008 - thelancet.com
Clinical asthma is very widely assumed to be the net result of excessive inflammation driven
by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then …
by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then …
Global strategy for asthma management and prevention: GINA executive summary
ED Bateman, SS Hurd, PJ Barnes… - European …, 2008 - Eur Respiratory Soc
Asthma is a serious health problem throughout the world. During the past two decades,
many scientific advances have improved our understanding of asthma and ability to manage …
many scientific advances have improved our understanding of asthma and ability to manage …
Targeting airway inflammation in asthma: current and future therapies
NA Hanania - Chest, 2008 - Elsevier
Asthma is a chronic inflammatory disease of the airway that requires long-term
antiinflammatory therapy. Inhaled corticosteroids (ICSs) are recommended for first-line …
antiinflammatory therapy. Inhaled corticosteroids (ICSs) are recommended for first-line …
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
E Goleva, PJ Hauk, CF Hall, AH Liu… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: The cause of corticosteroid-resistant (CR) asthma is unknown.
OBJECTIVE: We sought to perform gene microarray analyses by using bronchoalveolar …
OBJECTIVE: We sought to perform gene microarray analyses by using bronchoalveolar …
Severe childhood asthma: a common international approach?
Although most children with asthma are easy to treat with low doses of safe drugs, many
remain symptomatic despite every effort. 1 The nomenclature for this group is confused, and …
remain symptomatic despite every effort. 1 The nomenclature for this group is confused, and …
Sputum eosinophils and the response of exercise-induced bronchoconstriction to corticosteroid in asthma
ML Duong, P Subbarao, E Adelroth, G Obminski… - Chest, 2008 - Elsevier
Background The relationship between eosinophilic airway inflammation and exercise-
induced bronchoconstriction (EIB), and the response to inhaled corticosteroid (ICS) therapy …
induced bronchoconstriction (EIB), and the response to inhaled corticosteroid (ICS) therapy …
Inflammometry to assess airway diseases
The diagnostic labels used to characterise common airway diseases have always been a
problem. The term asthma implies the presence of variable airflow obstruction; however …
problem. The term asthma implies the presence of variable airflow obstruction; however …
Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a …
Background: A subset of patients with chronic obstructive pulmonary disease (COPD) may
respond more favorably to inhaled corticosteroids (ICS), but no simple method is currently …
respond more favorably to inhaled corticosteroids (ICS), but no simple method is currently …
Partitioned exhaled nitric oxide to non-invasively assess asthma
JL Puckett, SC George - Respiratory physiology & neurobiology, 2008 - Elsevier
Asthma is a chronic inflammatory disease of the lungs, characterized by airway
hyperresponsiveness. Chronic repetitive bouts of acute inflammation lead to airway wall …
hyperresponsiveness. Chronic repetitive bouts of acute inflammation lead to airway wall …
Aeroallergen sensitization correlates with PC20 and exhaled nitric oxide in subjects with mild-to-moderate asthma
TJ Craig, TS King, RF Lemanske Jr… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Aeroallergen sensitization in adult asthmatic patients from a wide
geographic area has not been correlated with patients' characteristics, markers of airways …
geographic area has not been correlated with patients' characteristics, markers of airways …