The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Despite the great importance of nonhematopoietic cells constituting the microenvironment
for normal hematopoiesis, the cellular interactions between nonhematopoietic cells …

Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand
Delta in signal-sending cells are required for activation of Notch signaling, but how these …

The N-methyl-d-aspartate receptor (NMDAR) plays a critical role in synaptic plasticity. Post-
translational modifications of NMDARs, such as phosphorylation, alter both the activity and …

Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell
interactions in various developmental processes. Numerous regulatory proteins interact with …

Notch signaling regulates lineage decisions at multiple stages of lymphocyte development,
and Notch activation requires the endocytosis of Notch ligands in the signal-sending cells …

Intraembryonic hematopoiesis occurs at two different sites, the floor of the aorta and
subaortic patches (SAPs) of the para-aortic splanchnopleura (P-Sp)/aorta-gonad …

The evolutionarily conserved Notch signaling pathway controls diverse events such as cell
fate determination, proliferation, apoptosis, and stem cell maintenance. Dysregulation of this …

Delta in signal-sending cells are required for activation of Notch signaling, but how these
events promote Notch activation remains poorly understood. Here we show that an …

I also investigated the involvement of lnvadolysin in Notch pathway. The Notch extracellular
domain levels were normal in the invadolysin mutants, but the intracellular domain levels …