Role of mechanical stress in regulating airway surface hydration and mucus clearance rates
B Button, RC Boucher… - Respiratory physiology …, 2008 - Elsevier
Effective clearance of mucus is a critical innate airway defense mechanism, and under
appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has …
appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has …
What's new in cystic fibrosis? From treating symptoms to correction of the basic defect
M Proesmans, F Vermeulen, K De Boeck - European journal of pediatrics, 2008 - Springer
Chronic relentless lung infection and pancreatic insufficiency are the cardinal features of
cystic fibrosis (CF), a life-shortening autosomal recessive disease. Mutations in the'cystic …
cystic fibrosis (CF), a life-shortening autosomal recessive disease. Mutations in the'cystic …
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells
IM Lorenzo, W Liedtke… - Proceedings of the …, 2008 - National Acad Sciences
The rate of mucociliary clearance in the airways is a function of ciliary beat frequency (CBF),
and this, in turn, is increased by increases in intracellular calcium. The TRPV4 cation …
and this, in turn, is increased by increases in intracellular calcium. The TRPV4 cation …
Shear stress regulates aquaporin-5 and airway epithelial barrier function
VK Sidhaye, KS Schweitzer… - Proceedings of the …, 2008 - National Acad Sciences
As the interface with the outside world, the airway epithelial barrier is critical to lung defense.
Because of respiratory efforts, the airways are exposed to shear stress; however, little is …
Because of respiratory efforts, the airways are exposed to shear stress; however, little is …
17β-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
RD Coakley, H Sun, LA Clunes… - The Journal of …, 2008 - Am Soc Clin Investig
Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …
Influenza A virus inhibits alveolar fluid clearance in BALB/c mice
KE Wolk, ER Lazarowski, ZP Traylor… - American journal of …, 2008 - atsjournals.org
Rationale: Pulmonary infections can impair alveolar fluid clearance (AFC), contributing to
formation of lung edema. Effects of influenza A virus (IAV) on AFC are unknown. Objectives …
formation of lung edema. Effects of influenza A virus (IAV) on AFC are unknown. Objectives …
Pharmacological properties of N-(3, 5-diamino-6-chloropyrazine-2-carbonyl)-N′-4-[4-(2, 3-dihydroxypropoxy) phenyl] butyl-guanidine methanesulfonate (552-02), a …
AJ Hirsh, J Zhang, A Zamurs, J Fleegle… - … of Pharmacology and …, 2008 - ASPET
Amiloride improves mucociliary clearance (MC) by blocking airway epithelial sodium
channels (ENaC) and expanding airway surface liquid (ASL). However, the low potency and …
channels (ENaC) and expanding airway surface liquid (ASL). However, the low potency and …
Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
CW Davis, E Lazarowski - Respiratory physiology & neurobiology, 2008 - Elsevier
The mucociliary clearance system is comprised of three components, ion transport activities
controlling the height of airway surface liquid (ASL), mucin secretion, and ciliary activity …
controlling the height of airway surface liquid (ASL), mucin secretion, and ciliary activity …
Mechano-sensitivity of ENaC: may the (shear) force be with you
M Fronius, WG Clauss - Pflügers Archiv-European Journal of Physiology, 2008 - Springer
Abstract The epithelial Na+ channel (ENaC) is the rate-limiting step for Na+ absorption in
various vertebrate epithelia and deeply enmeshed in the control of salt and water …
various vertebrate epithelia and deeply enmeshed in the control of salt and water …
Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl− transport in biliary epithelial cells through a PKCζ‐dependent pathway
ATP in bile is a potent secretogogue, stimulating cholangiocyte Cl− and fluid secretion via
binding to membrane P2 receptors, though the physiological stimuli involved in biliary ATP …
binding to membrane P2 receptors, though the physiological stimuli involved in biliary ATP …