Effective clearance of mucus is a critical innate airway defense mechanism, and under
appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has …

Chronic relentless lung infection and pancreatic insufficiency are the cardinal features of
cystic fibrosis (CF), a life-shortening autosomal recessive disease. Mutations in the'cystic …

The rate of mucociliary clearance in the airways is a function of ciliary beat frequency (CBF),
and this, in turn, is increased by increases in intracellular calcium. The TRPV4 cation …

As the interface with the outside world, the airway epithelial barrier is critical to lung defense.
Because of respiratory efforts, the airways are exposed to shear stress; however, little is …

Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …

Rationale: Pulmonary infections can impair alveolar fluid clearance (AFC), contributing to
formation of lung edema. Effects of influenza A virus (IAV) on AFC are unknown. Objectives …

Amiloride improves mucociliary clearance (MC) by blocking airway epithelial sodium
channels (ENaC) and expanding airway surface liquid (ASL). However, the low potency and …

The mucociliary clearance system is comprised of three components, ion transport activities
controlling the height of airway surface liquid (ASL), mucin secretion, and ciliary activity …

Abstract The epithelial Na+ channel (ENaC) is the rate-limiting step for Na+ absorption in
various vertebrate epithelia and deeply enmeshed in the control of salt and water …

ATP in bile is a potent secretogogue, stimulating cholangiocyte Cl− and fluid secretion via
binding to membrane P2 receptors, though the physiological stimuli involved in biliary ATP …