In this review, we give an overview of recent literature on the structure and stability of
unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

There are many structures that can be adopted by nucleic acids other than the famous
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a
simple method aiming at evaluating quadruplex-DNA binding affinity and quadruplex-over …

A series of square-planar and square-based pyramidal metal complexes (metal= Ni2+,
Cu2+, Zn2+, and V4+) with salphen and salen derivatives as ligands have been prepared …

Since the seminal report in 1997 on small molecules designed to interact with G-quadruplex
DNA,[1] an impressive number of candidates have been evaluated for binding to this …

G-quadruplex structures are promising targets for design of cancer drugs with high
selectivity and low toxicity. This review provides an update of the progress made over the …

The increasing resistance of Plasmodium falciparum to the most commonly used
antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of …

The human genome contains thousands of regions, including that of the telomere, that have
the potential to form quadruplex structures. Many of these regions are potential targets for …

DNA hairpin structures formed within a repeated tract might be a causative factor for triplet
expansion observed in several debilitating diseases. We have designed and used a …