Bile acids are increasingly being appreciated as complex metabolic integrators and
signalling factors and not just as lipid solubilizers and simple regulators of bile-acid …

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal
mass during adulthood, and the large capacity of bone to store calcium and phosphate …

FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated
by PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined …

The klotho gene functions as an aging-suppressor gene that extends life span when
overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho …

Abstract Fibroblast growth factor‐21 (FGF‐21) is a metabolic regulator that can influence
glucose and lipid control in diabetic rodents and primates. We demonstrate that βKlotho is …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Fibroblast growth factor (FGF) 23 is proposed to play a physiological role in the regulation of
phosphate and vitamin D metabolism; deranged circulatory levels of FGF23 cause several …

Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While
most FGFs were shown to work as local factors regulating cell growth and differentiation …

Maintenance of physiologic phosphate balance is of crucial biological importance, as it is
fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast …

Endocrine fibroblast growth factors (FGFs) control a variety of physiological processes
including suppression of bile acid synthesis in hepatocytes, promotion of lipolysis in …