Suicidal behavior is partly heritable. Studies seeking the responsible candidate genes have
examined genes involved in neurotransmitter systems shown to have altered function in …

Genetic epidemiology research has shown that genes contribute to suicide risk.
Unfortunately, the first 30 years of candidate-based association studies have provided little …

Abstract Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible
for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a …

Abstract The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range
of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is …

Suicide is among the top ten leading causes of death in individuals of all ages. An
explanatory model for suicidal behavior that links clinical and psychological risk factors or …

Impaired brain serotonin neurotransmission is a potential component of the diathesis of
major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic …

Objective Genetic variability within the serotoninergic system may predict the response to
antidepressant drugs. Several polymorphisms in the gene coding for the brain-specific …

The tryptophan hydroxylase 2 gene (TPH2) was resequenced at the 5′ upstream, coding,
and 3′ downstream regions, including all 11 exons in 185 subjects. Twenty-three novel …

BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin
synthesis. TPH2 is a recently discovered isoform that is expressed predominantly in …

Serotonin is implicated in stress-related psychopathologies. Two isoforms of the rate-limiting
enzyme of serotonin biosynthesis, tryptophan hydroxylase, TPH1 and TPH2, are known. We …