Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression by catalyzing the removal of acetyl groups, stimulating chromatin condensation …

Breast carcinogenesis involves genetic and epigenetic alterations that cause aberrant gene
function. Recent progress in the knowledge of epigenomics has had a profound impact on …

Epigenic modifications, mainly DNA methylation and acetylation, are recognized as the main
mechanisms contributing to the malignant phenotype. Acetylation and deacetylation are …

Vascular endothelial growth factor receptors (VEGFRs) perform pivotal roles in both tumor
growth and angiogenesis. In this study, we report that histone deacetylase inhibitors (HDIs) …

Purpose: To evaluate the potential utility of histone deacetylase inhibitors (HDACi) for
treatment of retinoblastoma (RB). Experimental Design: Growth-inhibitory effects of HDACi …

The heat shock protein 90 (Hsp90) chaperone is required for the conformational maturation
and stability of multiple oncogenic kinases that drive signal transduction and proliferation of …

Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing.
This review highlights the promising data for their combination with a wide range of …

Dysregulation of DNA methyltransferase (DNMT) 1 expression is associated with cellular
transformation, and inhibition of DNMT1 exerts antitumorigenic effects. Here, we report that …

Estrogen receptor α (ERα) plays an important role in the development and progression of
breast cancer, and recent studies showed that ERα expression is associated with resistance …

The molecular basis of the antitumor selectivity of histone deacetylase inhibitors (HDIs)
remains unclear. Centrosomal Aurora-A kinase regulates chromosomal segregation during …