DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate
detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells …

Smac/DIABLO is a protein released from mitochondria into the cytosol in response to
apoptotic stimuli. Smac promotes apoptosis at least in part through antagonizing inhibitor of …

Protein-protein interactions represent targets for drug discovery that are highly relevant in a
biological sense, but have proven difficult in a practical sense. Nevertheless, there have …

We describe the peptide-binding specificity of the baculoviral IAP repeat (BIR) domains of
the human inhibitor of apoptosis (IAP) proteins, X-linked IAP, cellular IAP1 and neuronal …

We have designed and synthesized a cyclic, bivalent Smac mimetic (compound 3) and
characterized its interaction with the X-linked inhibitor of apoptosis protein (XIAP) …

XIAP (X-chromosome-linked inhibitor of apoptosis protein) is an inhibitor of apoptosis by
binding to and inhibition of caspase-3 and caspase-7 through its BIR2 domain and caspase …

The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in several malignant
cells where it prevents apoptosis by binding to, and blocking, the activation of caspase-3,-7 …

Apoptosis, also called programmed cell death, is a conserved mechanism inherent to all
cells that sentences them to death when they receive the appropriate external stimuli …

[eng] Cancer is the second disease leading cause of death in industrialized countries.
Although early detection and more efficient drugs are responsible of the reduction of …

Signaling pathways control the fate of the cell. For example, they promote cell survival or
commit the cell to death (apoptosis) in response to cell injury or developmental stimuli …