The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone
resorption has led to major advances in our understanding of how bone modeling and …

Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …

Bone‐related diseases, such as osteoporosis and rheumatoid arthritis, affect hundreds of
millions of people worldwide and pose a tremendous burden to health care. By deepening …

Cyclin D1 (CyD1) is a pivotal cell cycle–regulatory molecule and a well-studied therapeutic
target for cancer. Although CyD1 is also strongly up-regulated at sites of inflammation, its …

Bone remodelling is an active and dynamic process that relies on the correct balance
between bone resorption by osteoclasts and bone deposition by osteoblasts. Moreover …

Certain autoimmune diseases result in abnormal bone homeostasis, but association of
immunodeficiency with bone is poorly understood. Osteoclasts, which derive from bone …

Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the
inhibitor of which has been considered might have therapeutic potential. We show that …

Osteoclastogenesis is a tightly regulated biological process, and deregulation can lead to
severe bone disorders such as osteoporosis. The regulation of osteoclastic signaling is …

TREM-1 (triggering receptor expressed on myeloid cells-1) is an orphan immunoreceptor
expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and …

OBJECTIVE: This study reports the expression of proinflammatory cytokines in
temporomandibular joint (TMJ) of patients affected with temporomandibular osteoarthritis …