Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

BACKGROUND: The importance of IL-13 in the asthma paradigm is supported by increased
expression in human subjects, particularly in patients with mild-to-moderate asthma …

There are over 100 genes that have been reported to be associated with asthma or related
phenotypes. In 2006–2007 alone there were 53 novel candidate gene associations reported …

The prevalence of atopic diseases has increased abruptly in recent years in most
Westernized societies, making the question why this happened the topic of a heated debate …

Objective: To present the most important and recent results of studies on asthma genetics.
These data may help general physicians understand the impact of genetics on this complex …

Background Tobacco smoke and genetic susceptibility are risk factors for asthma and
wheezing. The aim of this study was to investigate whether there is a combined effect of …

Studying gene–environment interactions may elucidate the complex origins of atopic
diseases but requires large study populations. Pooling data from several cohort studies may …

A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in
three case–control sample sets (1446 patients and 1432 controls) identified three IL13 …

Background Atopic eczema is characterized by Th2‐dominant immunity with the cytokine
interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role …

Asthma is a genetically complex disease caused by multiple genetic and environmental
factors. An increasing number of asthma susceptibility genes are currently being identified …