[HTML][HTML] Sleeping Beauty transposon‐mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

X Huang, H Guo, J Kang, S Choi, TC Zhou… - Molecular Therapy, 2008 - cell.com
We have reported earlier that the non‐viral Sleeping Beauty (SB) transposon system can
mediate genomic integration and long‐term reporter gene expression in human primary …

Transposon tools hopping in vertebrates

J Ni, KJ Clark, SC Fahrenkrug… - Briefings in Functional …, 2008 - academic.oup.com
In the past decade, tools derived from DNA transposons have made major contributions to
vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly …

Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions

DA Largaespada, LS Collier - Chromosomal Mutagenesis, 2008 - Springer
Understanding the genetic basis for tumor formation is crucial for treating cancer. Forward
genetic screens using insertional mutagenesis technologies have identified many important …

Liver-Directed Gene Therapy Using the Sleeping Beauty Transposon System

LR Belur, RS McIvor, A Wilber - Gene Therapy Protocols: Design and …, 2008 - Springer
Sleeping Beauty (SB) is a transposon system genetically reconstructed from teleost fish that
mediates chromosomal integration of DNA sequences by a cut-and-paste mechanism. SB …

Gene transfer to sperm and testis: future prospects of gene therapy for male infertility

Y Kojima, S Kurokawa, K Mizuno… - Current gene …, 2008 - ingentaconnect.com
Male infertility has been considered a major contributory factor to infertility. The causes of
spermatogenetic failure found in most cases of male infertility remain largely idiopathic …

Application of the Sleeping Beauty transposon system to avian cells

BW Kong, DF Carlson, SC Fahrenkrug… - Animal …, 2008 - Wiley Online Library
We have for the first time assessed the ability of the Sleeping Beauty (SB) transposon
system to enhance transgenesis in chicken and turkey cells. The efficiency of transgenesis …

New vaccination strategies for the improvement of DNA vaccines against virus in fish

C Tafalla¹, A Estepa, J Coll - Aquaculture research trends, 2008 - books.google.com
Vaccination seems like the most adequate method to control viral diseases in aquacultured
fish. Up to date, very few viral vaccines are commercialised, since it has been a difficult task …

Tiermodelle in der biomedizinischen Forschung

M Strehle, S Britisch - Grundlagen der Molekularen Medizin, 2008 - Springer
Auszug Die Entwicklung und Funktion komplexer biologischer Systeme, wie sie das Herz-
Kreislauf-System oder das menschliche Gehirn darstellen, unterliegen komplizierten …

Sleeping beauty transposion and its potential applications in cancer research

LI Yongwen, YAO Yibing, WAN Haisu… - Zhongguo Fei Ai Za …, 2008 - search.proquest.com
转座子, 或者叫跳跃基因, 最早由美国的细胞遗传学家 Mc-Clintock 在研究玉米时发现的 [1],
是指一些能够从一个染色体位置转移到另外的位置的核酸序列. Mc-Clintock …

Transposon-Mediated Mutagenesis in Somatic Cells

DA Largaespada, LS Collier - Chromosomal Mutagenesis - Springer
Understanding the genetic basis for tumor formation is crucial for treating cancer. Forward
genetic screens using insertional mutagenesis technologies have identified many important …