Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression

KU Wagner, H Rui - Journal of mammary gland biology and neoplasia, 2008 - Springer
During normal mammary gland development, the tyrosine kinase Jak2 and its main
substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the …

[PDF][PDF] Apoptosis and autophagy in involuting bovine mammary gland

J Zarzynska, T Motyl - J Physiol Pharmacol, 2008 - researchgate.net
Successful lactation depends on a controlled process of cell proliferation and mammary
gland growth during pregnancy and cell death during involution. The main type of cell death …

[HTML][HTML] cDNA microarray analysis reveals that antioxidant and immune genes are upregulated during involution of the bovine mammary gland

K Singh, SR Davis, JM Dobson, AJ Molenaar… - Journal of dairy …, 2008 - Elsevier
We have used cDNA microarray analysis to identify genes that play a role in bovine
mammary involution. Involution was induced by termination of milking, and alveolar tissue …

Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen

CKM Ho, J Nanda, KE Chapman… - Journal of …, 2008 - joe.bioscientifica.com
We studied the effects of TRH on the cytosolic free calcium concentration ([Ca2+] i) of female
rat pituitary prolactin-secreting (lactotroph) and GH-secreting (somatotroph) cells in the early …

Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution

JA Sharp, C Lefèvre, KR Nicholas - BMC biology, 2008 - Springer
Background The mammary gland undergoes a sophisticated programme of developmental
changes during pregnancy/lactation. However, little is known about processes involving …

Effect of continuous milking and prostaglandin E2 on milk production and mammary epithelial cell turnover, ultrastructure, and gene expression

EL Annen, CM Stiening, BA Crooker… - Journal of animal …, 2008 - academic.oup.com
Mammary epithelial cell (MEC) growth is reduced in continuously milked (CM) mammary
glands, and administration of a mammogenic compound such as prostaglandin E2 (PGE2) …

Cellular expression of Bcl‐2 and Bax in atrophic submandibular glands of rats

S Takahashi, Y Yoshimura… - International journal …, 2008 - Wiley Online Library
In submandibular gland atrophy, most acinar cells disappear by apoptosis, while many duct
cells remain. The present study aimed to establish whether Bcl‐2 and Bax, members of the …

A population of mammary epithelial cells do not require hormones or growth factors to survive

AJ Brennan, J Sharp, E Khalil, MR Digby, SL Mailer… - 2008 - dro.deakin.edu.au
Hormonal stimulation of mammary explants mimics many of the biochemical changes
observed during lactogenesis. Previous studies using eutherian species conclude that …

西农萨能山羊锌指蛋白基因Ubi-d4 的筛选, 克隆和生物信息学分析

武会娟, 罗军, 张丽娟, 杨宝进, 韩雪峰, 王海滨 - 中国农业科学, 2008 - chinaagrisci.com
Ubi-d4, belonging to d4 gene family, it involves in apoptosis response and modulates cell
growth and turnover. The object of this study was to identify and verify if Ubi-d4 was involved …

Identification de nouvelles cibles du Tamoxifène impliquées dans son activité pharmacologique

B Payre - 2008 - theses.fr
Le tamoxifène (Tam) est le principal médicament utilisé dans le monde en hormonothérapie
des cancers du sein qui expriment les récepteurs des oestrogènes. Dans une première …