Accumulating evidence supports the importance of redox signaling in the pathogenesis and
progression of hypertension. Redox signaling is implicated in many different physiological …

Protein‐tyrosine phosphatases are tightly controlled by various mechanisms, ranging from
differential expression in specific cell types to restricted subcellular localization, limited …

The proliferation of vascular smooth muscle cells is important in the pathogenesis of many
vascular diseases. Reactive oxygen species (ROS) produced by NADPH oxidases in …

A defining characteristic of solid tumors is the capacity to divide aggressively and
disseminate under conditions of nutrient deprivation, limited oxygen availability, and …

Angiotensin II (Ang II) signaling in vascular smooth muscle cells (VSMCs) involves reactive
oxygen species (ROS) through unknown mechanisms. We propose that Ang II induces …

Vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-
derived growth factor (PDGF) play an important role in the development of atherosclerosis …

Background/Aims: Growth factor and oxidative stress-mediated migration and proliferation of
vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of …

Platelet-derived growth factor (PDGF) isoforms stimulate cell proliferation, migration and
survival. We recently generated mice carrying a gain-of-function mutation within the …

Angiotensin II (Ang II) and platelet-derived growth factor-BB (PDGF-BB) are associated with
excessive cell migration, proliferation and many growth-related diseases. However, whether …

Reactive oxygen species (ROS) have been implicated in vascular smooth muscle cell
(VSMC) apoptosis, a hallmark of advanced atherosclerotic lesions. Transient oxidation and …