Introducing sense into nonsense in treatments of human genetic diseases
L Linde, B Kerem - Trends in genetics, 2008 - cell.com
Approximately one-third of alleles causing genetic diseases carry premature termination
codons (PTCs), which lead to the production of truncated proteins. The past decade has …
codons (PTCs), which lead to the production of truncated proteins. The past decade has …
Recognition and elimination of nonsense mRNA
O Mühlemann, AB Eberle, L Stalder… - Biochimica et Biophysica …, 2008 - Elsevier
Among the different cellular surveillance mechanisms in charge to prevent production of
faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation …
faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation …
Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
JC Schöning, C Streitner, IM Meyer, Y Gao… - Nucleic acids …, 2008 - academic.oup.com
The Arabidopsis RNA-binding protein At GRP8 undergoes negative autoregulation at the
post-transcriptional level. An elevated At GRP8 protein level promotes the use of a cryptic …
post-transcriptional level. An elevated At GRP8 protein level promotes the use of a cryptic …
[HTML][HTML] Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues
AB Zetoune, S Fontanière, D Magnin, O Anczuków… - BMC genetics, 2008 - Springer
Abstract Background The Nonsense-Mediated mRNA Decay (NMD) pathway detects and
degrades mRNAs containing premature termination codons, thereby preventing the …
degrades mRNAs containing premature termination codons, thereby preventing the …
Studying nonsense-mediated mRNA decay in mammalian cells
Nonsense-mediated decay (NMD) in eukaryotic cells largely functions as a quality control
mechanism by degrading faulty mRNAs that terminate translation prematurely. In recent …
mechanism by degrading faulty mRNAs that terminate translation prematurely. In recent …
Identifying Substrates of mRNA Decay Factors by a Combined RNA Interference and DNA Microarray Approach
J Wittmann, HM Jäck - Methods in enzymology, 2008 - Elsevier
The complex control of gene expression has many layers, and the modulation of
posttranscriptional events receives more and more attention as a focus of research. In this …
posttranscriptional events receives more and more attention as a focus of research. In this …