The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis

EP Cummins, F Seeballuck, SJ Keely, NE Mangan… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Prolyl and asparaginyl hydroxylases are key oxygen-sensing
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …

Gossypol suppresses NF-κB activity and NF-κB-related gene expression in human leukemia U937 cells

DO Moon, MO Kim, JD Lee, GY Kim - Cancer letters, 2008 - Elsevier
Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in
vivo. The nuclear factor-kappa B (NF-κB) plays an important role in tumor cell growth …

Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-κB activation

BS Marasa, L Xiao, JN Rao, T Zou… - … of Physiology-Cell …, 2008 - journals.physiology.org
Transient receptor potential canonical-1 (TRPC1) functions as a store-operated Ca2+
channel in intestinal epithelial cells (IECs), and induced TRPC1 expression sensitizes IECs …

Focal adhesion kinase mediates the interferon‐γ‐inducible GTPase‐induced phosphatidylinositol 3‐kinase/Akt survival pathway and further initiates a positive …

Z Liu, HM Zhang, J Yuan, T Lim, A Sall… - Cellular …, 2008 - Wiley Online Library
Interferon‐γ‐inducible GTPase (IGTP) expression is upregulated in coxsackievirus B3
(CVB3)‐infected murine heart and inhibits CVB3‐induced apoptosis through activation of …

[HTML][HTML] Focal adhesion kinase mediates the IGTP-induced PI3K/Akt survival pathway and further initiates a positive feedback loop of NF-κB activation

Z Liu, HM Zhang, J Yuan, T Lim, A Sall… - Cellular …, 2008 - ncbi.nlm.nih.gov
Interferon-γ-inducible GTPase (IGTP) expression is upregulated in coxsackievirus B3
(CVB3)-infected murine heart and inhibits CVB3-induced apoptosis through activation of the …