The cellular response to genotoxic stress includes cell-cycle arrest, activation of DNA repair
and induction of apoptosis. However, the signals that determine cell fate are largely …

Abstract mTOR, the mammalian target of rapamycin, is a critical target of survival signals in
many human cancers. In the absence of serum, rapamycin induces apoptosis in MDA-MB …

Oxidative stress has been shown to mediate neuron damage in Parkinson's disease (PD). In
the present report, we intend to clarify the intracellular pathways mediating dopaminergic …

Conventional and novel protein kinase C (PKC) isozymes are the main targets of tumor
promoters. We developed 1-hexylindolactam-V10 (5) as a selective activator for novel PKC …

Oncogene HCCR‐1 functions as a negative regulator of the p53 and contributes to
tumorigenesis of various human tissues. HCCR transgenic mice developed breast cancers …

Background We have investigated the role of protein kinase C (PKC) in the mechanism of
cerebral vasospasm, and showed the pivotal roles of PKC isoforms (PKC δ and α) in that …

Dusp dual specificity phosphatase ECL enhanced chemolumineszenz EDTA
Ethylendiamintetraacetat EGF Epidermal growth factor Egr1 Early growth response 1 ERK …

A harántcsíkolt izom egyik jellegzetes tulajdonsága, hogy nagyfokú in vivo és in vitro
regenerációs képességgel rendelkezik, mely központi szerepet játszik a sérülést követő …

There is an escalating demand in the area of cancer prevention and control for the
development of novel agents and molecular targets that have potential to reduce the …

Phospholipase D (PLD) is a phosphodiesterase that hydrolyzes phosphatidylcholine into
phosphatidic acid (PA) and choline. In untransformed cells, PLD activity is stimulated by …