Atrial remodeling and atrial fibrillation: mechanisms and implications
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …
age but is very rare in children and becomes extremely common in the elderly, with a …
Cardiac fibrillation: from ion channels to rotors in the human heart
Recent new information on the dynamics and molecular mechanisms of electrical rotors and
spiral waves has increased our understanding of both atrial fibrillation and ventricular …
spiral waves has increased our understanding of both atrial fibrillation and ventricular …
Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current
Atrial tachycardia (AT) downregulates L-type Ca2+ current (I CaL) and causes atrial
fibrillation–promoting electric remodeling. This study assessed potential underlying signal …
fibrillation–promoting electric remodeling. This study assessed potential underlying signal …
[HTML][HTML] Pathology-specific effects of the IKur/Ito/IK, ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation
Background and purpose This study was designed to establish the pathology-specific
inhibitory effects of the I Kur/I to/IK, ACh blocker AVE0118 on atrium-selective channels and …
inhibitory effects of the I Kur/I to/IK, ACh blocker AVE0118 on atrium-selective channels and …
Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes
Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent,
constitutively active, acetylcholine-regulated K+-current (IK, ACh) that increases …
constitutively active, acetylcholine-regulated K+-current (IK, ACh) that increases …
Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics
Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …
Inward rectifier potassium currents as a target for atrial fibrillation therapy
JR Ehrlich - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Subunits of inwardly rectifying potassium channels (Kir) are expressed in many different
tissues of the human body. Inward rectifier currents expressed in the heart are constituted by …
tissues of the human body. Inward rectifier currents expressed in the heart are constituted by …
[HTML][HTML] Cellular bases for human atrial fibrillation
AJ Workman, KA Kane, AC Rankin - Heart Rhythm, 2008 - Elsevier
Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and
sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular …
sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular …
M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gβγ-mediated inhibition of large conductance Ca2+-activated K+ channel activity
XB Zhou, I Wulfsen, S Lutz, E Utku, U Sausbier… - Journal of Biological …, 2008 - ASBMB
Airway smooth muscle is richly endowed with muscarinic receptors of the M 2 and M 3
subtype. Stimulation of these receptors inhibits large conductance calcium-activated K+(BK) …
subtype. Stimulation of these receptors inhibits large conductance calcium-activated K+(BK) …
[HTML][HTML] How do atrial-selective drugs differ from antiarrhythmic drugs currently used in the treatment of atrial fibrillation?
A Burashnikov, C Antzelevitch - Journal of atrial fibrillation, 2008 - ncbi.nlm.nih.gov
Current pharmacologic strategies for the management of atrial fibrillation (AF) include use of
1) sodium channel blockers, which are contraindicated in patients with coronary artery or …
1) sodium channel blockers, which are contraindicated in patients with coronary artery or …