Reversible protein acetylation is controlled by the opposing actions of protein lysine
acetyltransferases and deacetylations. Recent developments on the structure and …

The histone-modifying enzymes that catalyze reversible lysine acetylation and methylation
are central to the epigenetic regulation of chromatin remodeling. From the early discovery of …

The recent structure and associated biochemical studies of the metazoan-specific p300/CBP
and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights …

Rtt109, also known as KAT11, is a recently characterized fungal-specific histone
acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome …

Epigenetics is the study of differences in phenotype, in the absence of variation in the
genetic code. Epigenetics is relevant in the pathogenesis of many skin diseases. In the case …

Rtt109 is a protein acetyltransferase (PAT) that is responsible for the acetylation of lysine-56
of histone 3 (H3K56) in yeast. H3K56 acetylation has been implicated in the weakening of …

Histone acetylation plays important roles for the regulation of many fundamental cellular
processes. Saccharomyces cerevisiae Rtt109 is an important class of histone …

www. landesbioscience. com Cell Cycle 2 that act as general bases in deprotonating the N-ε-
nitrogen of the target Lys for nucleophilic attack by the acetyl group of the bound AcCoA. 2 …

目的检测人胚肺成纤维细胞复制性衰老及过氧化氢诱导细胞早衰过程中组蛋白整体乙酰化修饰
的改变. 方法应用细胞免疫荧光实验观察组蛋白乙酰化水平变化, 并基于ELISA …

Previous studies have shown that loss of the type B histone acetyltransferase Hat1p leads to
defects in telomeric silencing in Saccharomyces cerevisiae. We used this phenotype to …