Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope,
thereby connecting the nuclear interior with the cytoplasm. Until recently, these …

Ageing and the mortality that ensues are sustainable for the species only if age is reset in
newborns. In budding yeast, buds are made young whereas ageing factors, such as …

During mitosis in higher eukaryotes, nuclear pore complexes (NPCs) disassemble in
prophase and are rebuilt in anaphase and telophase. NPC formation is hypothesized to …

Serving as the primary conduit for communication between the nucleus and the cytoplasm,
nuclear pore complexes (NPCs) impact nearly every cellular process. The extent to which …

Assembly of the nuclear pore, gateway to the genome, from its component subunits is a
complex process. In higher eukaryotes, nuclear pore assembly begins with the binding of …

The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the
cytoplasm and constitutes a central component of intracellular architecture. During mitosis in …

In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through
nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in …

Nuclear pore complexes (NPCs) are multisubunit protein entities embedded into the nuclear
envelope (NE). Here, we examine the in vivo dynamics of the essential Drosophila …

We recently proposed a cylindrical coat for the nuclear pore membrane in the nuclear pore
complex (NPC). This scaffold is generated by multiple copies of seven nucleoporins. Here …