Interleukin‐1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin‐1 receptor antagonist–deficient mice
MI Koenders, I Devesa, RJ Marijnissen… - … : Official Journal of …, 2008 - Wiley Online Library
Objective Interleukin‐1 receptor antagonist–deficient (IL‐1Ra−/−) mice spontaneously
develop an inflammatory and destructive arthritis due to unopposed excess IL‐1 signaling …
develop an inflammatory and destructive arthritis due to unopposed excess IL‐1 signaling …
Shift from Toll‐like receptor 2 (TLR‐2) toward TLR‐4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR‐4–mediated …
S Abdollahi‐Roodsaz, LAB Joosten… - … : Official Journal of …, 2008 - Wiley Online Library
Abstract Objective Toll‐like receptors (TLRs) may activate innate and adaptive immune
responses in rheumatoid arthritis (RA) through recognition of microbial as well as …
responses in rheumatoid arthritis (RA) through recognition of microbial as well as …
Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes
Objective Blocking tumor necrosis factor (TNF) effectively inhibits inflammation and joint
damage in rheumatoid arthritis (RA), but 40% of RA patients respond only transiently or not …
damage in rheumatoid arthritis (RA), but 40% of RA patients respond only transiently or not …
T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll‐like receptor–driven pathways: crucial role of both interleukin‐1β …
LAB Joosten, S Abdollahi‐Roodsaz… - Arthritis & …, 2008 - Wiley Online Library
Objective The pathogenesis of rheumatoid arthritis is often linked to bacterial infections. The
present study was undertaken to develop a mouse model of chronic destructive arthritis …
present study was undertaken to develop a mouse model of chronic destructive arthritis …
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
LAB Joosten, B Heinhuis… - Proceedings of the …, 2008 - National Acad Sciences
The pathogenesis of chronic joint inflammation remains unclear, although the involvement of
pathogen recognition receptors has been suggested recently. In the present article, we …
pathogen recognition receptors has been suggested recently. In the present article, we …
High levels of serum IL-18 promote cartilage loss through suppression of aggrecan synthesis
H Inoue, K Hiraoka, T Hoshino, M Okamoto, T Iwanaga… - Bone, 2008 - Elsevier
Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has
been reported that older age is associated with higher serum levels of the inflammatory …
been reported that older age is associated with higher serum levels of the inflammatory …
The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis
M Stolina, B Bolon, D Dwyer, S Middleton, D Duryea… - Biomarkers, 2008 - Taylor & Francis
Rats with collagen-induced arthritis (CIA) were necropsied on 14 occasions from 4 days
after induction to 27 days after disease onset to evaluate the kinetics of local (joint protein …
after induction to 27 days after disease onset to evaluate the kinetics of local (joint protein …
The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis …
N Takahashi, VCL de Jager, A Glück… - … : Official Journal of …, 2008 - Wiley Online Library
Objective Repeated injection of streptococcal cell wall (SCW) fragments results in chronic
arthritis in mice. The objective of this study was to identify genes and pathways that …
arthritis in mice. The objective of this study was to identify genes and pathways that …
Combined blockade of GM-CSF and IL-17 pathways potently suppresses chronic destructive arthritis in a TNFαindependent mouse model
C Plater-Zyberk, LAB Joosten, MMA Helsen… - Annals of the …, 2008 - ard.bmj.com
Objective: A pathogenic role for both GM-CSF and IL-17 in rheumatoid arthritis (RA) has
been suggested. In previously published papers, we have described the therapeutic …
been suggested. In previously published papers, we have described the therapeutic …
[PDF][PDF] Der Einfluss von TNF-α [TNF-alpha] und IL-1β [IL-1beta] auf die Knorpeldestruktion durch synoviale Fibroblasten: Untersuchungen in einem In-vitro …
D Pretzel - 2008 - db-thueringen.de
Abbildung 15: Aggrekanase I-mRNA-Expression im Knorpel der Knorpel MK (n= 3) bzw.
nach der KK mit RA-SFB (n= 4) oder OA-SFB (n= 3)(A) sowie in RA-SFB (n= 4) oder OA-SFB …
nach der KK mit RA-SFB (n= 4) oder OA-SFB (n= 3)(A) sowie in RA-SFB (n= 4) oder OA-SFB …