There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

The predominant molecular symptom of aging is the accumulation of altered gene products.
Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox …

Astrocytes play an important role in nervous system homeostasis. In particular, they
contribute to the regulation of local energy metabolism and to oxidative stress defence. In …

Gap junctions facilitate direct cytoplasmic communication between neighboring cells,
facilitating the transfer of small molecular weight molecules involved in cell signaling and …

This paper reviews the current ideas on nitric oxide (NO) physiology in brain and other
mammalian organs and on the subcellular distribution of nitric oxide synthases (NOS) …

The present study was conducted to investigate whether the conditionally essential amino
acid taurine could play any protective role against the potent neurotoxin cadmium (Cd) …

Hypobaric hypoxia, characteristic of high altitude is known to increase the formation of
reactive oxygen and nitrogen species (RONS), and decrease effectiveness of antioxidant …

NO synthesis disturbances play an important role in the development of neurodegenerative
damage in Alzheimer disease. We previously showed that adaptation to intermittent …

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the
substantial accumulation of data covering nutrienal modulation of gene expression at the …

Age related changes in brain cortex NO metabolism were investigated in mitochondria and
cytosolic extracts from youth to adulthood. Decreases of 19%, 40% and 71% in NO …