Acute lymphoblastic leukaemia

CH Pui, LL Robison, AT Look - The Lancet, 2008 - thelancet.com
Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects
both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady …

Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years

H Kantarjian, S O'Brien, J Cortes, W Wierda, S Faderl… - Cancer, 2008 - Wiley Online Library
Major therapeutic progress has been accomplished in leukemia and myelodysplastic
syndrome (MDS) over the past 40 years, which may not be fully appreciated by the larger …

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission …

AH Goldstone, SM Richards… - Blood, The Journal …, 2008 - ashpublications.org
An international collaboration was set up to prospectively evaluate the role of allogeneic
transplantation for adults with acute lymphoblastic leukemia (ALL) and compare autologous …

Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study

V Pullarkat, ML Slovak, KJ Kopecky… - Blood, The Journal …, 2008 - ashpublications.org
We examined the prognostic impact of cytogenetics on the outcome of 200 acute
lymphoblastic leukemia (ALL) patients 15 to 65 years of age enrolled in Southwest Oncology …

Long-term remission of Philadelphia chromosome–positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling …

GG Laport, JC Alvarnas, JM Palmer… - Blood, The Journal …, 2008 - ashpublications.org
Allogeneic hematopoietic cell transplantation (HCT) is the only known curative modality for
patients with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) …

Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease

K Paulsson, JB Cazier, F MacDougall… - Proceedings of the …, 2008 - National Acad Sciences
We present here a genome-wide map of abnormalities found in diagnostic samples from 45
adults and adolescents with acute lymphoblastic leukemia (ALL). A 500K SNP array …

[HTML][HTML] Biologic features and treatment outcome of secondary acute lymphoblastic leukemia—a review of 101 cases

R Shivakumar, W Tan, GE Wilding, ES Wang… - Annals of oncology, 2008 - Elsevier
Background Secondary acute lymphoblastic leukemia (sALL) is a rare disease and its
biologic features are not well characterized. Patients and methods We describe a cohort of …

Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission

DI Marks, WS Pérez, W He, MJ Zhang… - Blood, The Journal …, 2008 - ashpublications.org
We report the retrospective outcomes of unrelated donor (URD) transplants in 169 patients
with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) who received …

Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B …

K Mrózek, AJ Carroll, K Maharry… - International …, 2008 - spandidos-publications.com
The Cancer and Leukemia Group B has performed central review of karyotypes submitted
by institutional cytogenetics laboratories from patients with acute myeloid (AML) and acute …

[HTML][HTML] A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation

P Armand, HT Kim, CS Cutler, VT Ho, J Koreth… - Biology of Blood and …, 2008 - Elsevier
Allogeneic hematopoietic stem cell transplantation (SCT) has the potential to cure patients
with acute leukemia or myelodysplastic syndromes (MDS), but a number of prognostic …