Acromegaly

P Chanson, S Salenave - Orphanet journal of rare diseases, 2008 - Springer
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH)
and characterized by progressive somatic disfigurement (mainly involving the face and …

Growth hormone, IGF‐I and insulin and their abuse in sport

RIG Holt, PH Sönksen - British journal of pharmacology, 2008 - Wiley Online Library
There is widespread anecdotal evidence that growth hormone (GH) is used by athletes for
its anabolic and lipolytic properties. Although there is little evidence that GH improves …

Extensive clinical experience: changing patterns in diagnosis and therapy of acromegaly over two decades

L Nachtigall, A Delgado, B Swearingen… - The Journal of …, 2008 - academic.oup.com
Background: The increased morbidity and mortality of acromegaly makes early diagnosis
and therapy critical. However, whether the type of medical professional who first diagnoses …

GH and IGF‐I excess control contributes to blood pressure control: results of an observational, retrospective, multicentre study in 105 hypertensive acromegalic …

A Colao, M Terzolo, M Bondanelli… - Clinical …, 2008 - Wiley Online Library
Context Approximately one‐third of patients with acromegaly have concomitant
hypertension. The outcome of hypertension after treatment of acromegaly is unknown …

Long-term effects of pegvisomant in patients with acromegaly

I Hodish, A Barkan - Nature clinical practice Endocrinology & …, 2008 - nature.com
Despite improved surgical and radiotherapy techniques and the development of long-acting
somatostatin analogs, some patients with acromegaly cannot attain biochemical remission …

Therapeutic options in the management of acromegaly: focus on lanreotide Autogel®

F Roelfsema, NR Biermasz, AM Pereira… - Biologics: Targets and …, 2008 - Taylor & Francis
Background In acromegaly, expert surgery is curative in only about 60% of patients.
Postoperative radiation therapy is associated with a high incidence of hypopituitarism and its …

[PDF][PDF] Insulin-like growth factor-1 in plasma and brain: regulation in health and disease

C Sievers, HJ Schneider, GK Stalla - Front Biosci, 2008 - article.imrpress.com
[Frontiers in Bioscience 13, 85-99, January 1, 2008] 85 Insulin-like growth factor-1 in plasma
and brain: regulation in health Page 1 [Frontiers in Bioscience 13, 85-99, January 1, 2008] 85 …

The role of pegvisomant in the treatment of acromegaly

F Roelfsema, NR Biermasz, AM Pereira… - Expert opinion on …, 2008 - Taylor & Francis
Background: Expert surgery in acromegaly is curative in about only 60% of cases.
Postsurgical radiation therapy is associated with a high incidence of hypopituitarism and its …

Emerging drugs for acromegaly

P Chanson - Expert Opinion on Emerging Drugs, 2008 - Taylor & Francis
Background: Acromegaly is due to growth hormone (GH) hypersecretion by a benign
pituitary tumor (adenoma). Treatments include surgical removal of the adenoma (often …

Identification, treatment and management of cardiovascular risks in patients with acromegaly

F Bogazzi, M Lombardi, C Cosci… - Expert review of …, 2008 - Taylor & Francis
Acromegaly, a syndrome related to growth hormone/IGF-1 excess, is frequently complicated
by cardiovascular abnormalities (acromegalic cardiomyopathy). Extremely frequent are left …