The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are the
two most important mechanisms that normally repair or remove abnormal proteins …

The identification of the first gene in familial Parkinson's disease (PD) only 10 years ago was
a major step in the understanding of the molecular mechanisms in neurodegeneration …

Parkinson disease (PD) is the most common neurodegenerative movement disorder. An
increase in the amount of α-synuclein protein could constitute a cause of PD. α-Synuclein is …

The objective of this study was to explore combined effects of four candidate susceptibility
genes and two exposures on Parkinson's disease (PD) risk; namely, α-synuclein (SNCA) …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. The I93M mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is …

Abstract Abstract Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or
thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, after
Alzheimer's disease. In PD'motor symptoms result from the degeneration and loss of …

The author evaluated the implications of nominal statistical significance for changing the
credibility of null versus alternative hypotheses across a large number of observational …

A number of studies have associated the S18Y polymorphic variant of UCH-L1 with
protection from sporadic Parkinson's Disease (PD). The mechanism involved in this …

Parkinson's disease is a progressive age-related neurodegenerative disease with invariant
loss of substantia nigra dopamine neurons and striatal projections. This disorder is well …