As the recognition that costimulatory signals are critical for optimal T‐cell activation,
proliferation, and differentiation, there has been an explosion in the study of costimulatory …

Memory T-cell-specific therapeutics in organ transplantation : Current Opinion in Organ
Transplantation Memory T-cell-specific therapeutics in organ transplantation : Current Opinion …

The rapid effector functions and tissue heterogeneity of memory T cells facilitate protective
immunity, but they can also promote immunopathology in antiviral immunity, autoimmunity …

Memory T cells promote allograft rejection particularly in co-stimulation blockade–based
immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept …

In allogeneic hemopoietic stem cell transplantation, mature donor αβ T cells in the allograft
promote T cell reconstitution in the recipient and mediate the graft-vs-leukemia (GVL) effect …

BACKGROUND: Among the many potential risk factors influencing the development of
bronchiolitis obliterans syndrome (BOS), acute cellular rejection is the most frequently …

BACKGROUND: Cytomegalovirus (CMV) infection has been associated with allograft
rejection in solid organ transplantation. However, the immunologic mechanisms behind this …

Alloreactive T-cell memory is present in every transplant recipient and endangers graft
survival. Even in the absence of known sensitizing exposures, heterologous immunity and …

BACKGROUND: Solid organ transplant centers are increasingly using induction
immunosuppression strategies. Induction immunosuppression involves the use of intense …

The impact of memory B cells and alloantibodies on the ability to induce transplantation
tolerance has not been elucidated. We have developed a murine heart transplant model that …