There is a growing body of evidence suggesting that alterations in the adhesion properties
of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes …

Metastasis remains the overwhelming cause of death for cancer patients. During metastasis,
cancer cells will leave the primary tumor, intravasate into the bloodstream, arrest at a distant …

Bone is one of the most common sites of breast cancer metastasis while bone sialoprotein
(BSP) is thought to play an important role in bone metastasis of malignant tumors. The …

Bone sialoprotein (BSP) is a secreted glycoprotein found in mineralized tissues however,
BSP is aberrantly expressed in a variety of osteotropic tumors. Elevated BSP expression in …

Integrins constitute a family of cell surface receptors that are heterodimers composed of
noncovalently associated α and β subunits. Integrins bind to extracellular matrix proteins …

In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade
through tissues, and attach to a second site. The transcription factor snail is an important …

Bone sialoprotein (BSP) is a major non‐collagenous protein in mineralizing connective
tissues such as dentin, cementum and calcified cartilage tissues. As a member of the Small …

目的构建抑制人日5P 基因表达的RNA 干扰逆转录病毒载体, 筛选建立稳定抑制BSP
表达的MDA-MB-231BO 细胞系. 方法构建靶向人BSP 基因的逆转录病毒重组质粒pSilencer …

Prostate cancer is initially androgen-dependent (AD) and therefore androgen deprivation
therapy (ADT) is generally used to treat advanced prostate cancer. However, the long-term …