Wnt signaling is crucial for embryonic development in all animal species studied to date. The
interaction between Wnt proteins and cell surface receptors can result in a variety of …

The Wnt family of secreted ligands act through many receptors to stimulate distinct
intracellular signalling pathways in embryonic development, in adults and in disease …

In the past few years, our molecular understanding of bone formation has continued to
increase. This review aims to present a comprehensive view of the current state of …

It has been two decades since investigators discovered the link between the Drosophila
wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of …

Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by
diverse etiology, activation of multiple signal transduction pathways, and various gene …

Low-density lipoprotein receptor related proteins 5 and 6 (LRP5/6) are transmembrane
receptors that initiate Wnt/β-catenin signaling. Phosphorylation of PPPSP motifs in the LRP6 …

In response to Wnt stimulation, β-catenin accumulates and activates target genes. Using
modeling and experimental analysis, we found that the level of β-catenin is sensitive to …

Dishevelled (Dvl) is an essential protein in the Wnt signaling pathways; it uses its PDZ
domain to transduce the Wnt signals from the membrane receptor Frizzled to downstream …

The early vertebrate skeletal muscle is a well-organized tissue in which the primitive muscle
fibres, the myocytes, are all parallel and aligned along the antero-posterior axis of the …

β-catenin is an essential component of two cellular systems: cadherin-based adherens
junctions (AJ) and the Wnt signaling pathway. A functional or physical connection between …