Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery

D Vaudry, A Falluel-Morel, S Bourgault, M Basille… - Pharmacological …, 2009 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

VPAC and PAC receptors: from ligands to function

L Dickson, K Finlayson - Pharmacology & therapeutics, 2009 - Elsevier
Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating
polypeptides (PACAPs) share 68% identity at the amino acid level and belong to the …

Leydig cells: from stem cells to aging

H Chen, RS Ge, BR Zirkin - Molecular and cellular endocrinology, 2009 - Elsevier
Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell
population ultimately develops from undifferentiated mesenchymal-like stem cells present in …

Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of …

SE Hammack, J Cheung, KM Rhodes… - …, 2009 - Elsevier
Exposure to chronic stress has been argued to produce maladaptive anxiety-like behavioral
states, and many of the brain regions associated with stressor responding also mediate …

PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling

Z Hawke, TR Ivanov, DA Bechtold… - Journal of …, 2009 - Soc Neuroscience
The adipose-derived hormone, leptin, was discovered over 10 years ago, but only now are
we unmasking its downstream pathways which lead to reduced energy intake (feeding) and …

Neuroendocrine systems of the fish brain

JM Cerdá‐Reverter, LF Canosa - Fish physiology, 2009 - Elsevier
Publisher Summary This chapter discusses the neuroendocrine territories in fish. It
describes the anatomy of the main neuroendocrine territories of the teleost brains. Teleost …

Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology

MD Gahete, M Durán‐Prado, RM Luque… - Annals of the New …, 2009 - Wiley Online Library
Control of postnatal growth is the main, but not the only, role for growth hormone (GH) as this
hormone also contributes to regulating metabolism, reproduction, immunity, development …

Two Chromogranin A-Derived Peptides Induce Calcium Entry in Human Neutrophils by Calmodulin-Regulated Calcium Independent Phospholipase A2

D Zhang, P Shooshtarizadeh, BJ Laventie, DA Colin… - PLoS …, 2009 - journals.plos.org
Background Antimicrobial peptides derived from the natural processing of chromogranin A
(CgA) are co-secreted with catecholamines upon stimulation of chromaffin cells. Since …

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

YV Tan, C Abad, R Lopez, H Dong… - Proceedings of the …, 2009 - National Acad Sciences
Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a widely expressed
neuropeptide originally discovered in the hypothalamus. It closely resembles vasoactive …

Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system

L Mounien, JC Do Rego, P Bizet, I Boutelet… - …, 2009 - nature.com
Pituitary adenylate cyclase-activating polypeptide (PACAP) and the proopiomelanocortin
(POMC)-derived peptide, α-melanocyte-stimulating hormone (α-MSH), exert anorexigenic …