Linking DNA methylation and histone modification: patterns and paradigms

H Cedar, Y Bergman - Nature Reviews Genetics, 2009 - nature.com
Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

[HTML][HTML] CpG islands–'a rough guide'

RS Illingworth, AP Bird - FEBS letters, 2009 - Elsevier
Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

G Lal, N Zhang, W Van Der Touw, Y Ding… - The Journal of …, 2009 - journals.aai.org
Foxp3, a winged-helix family transcription factor, serves as the master switch for CD4+
regulatory T cells (Treg). We identified a unique and evolutionarily conserved CpG-rich …

Developmental programming of CpG island methylation profiles in the human genome

R Straussman, D Nejman, D Roberts… - Nature structural & …, 2009 - nature.com
CpG island–like sequences are commonly thought to provide the sole signals for
designating constitutively unmethylated regions in the genome, thus generating open …

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

M Kansara, M Tsang, L Kodjabachian… - The Journal of …, 2009 - Am Soc Clin Investig
Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and
expansion and forms the basis for novel anabolic therapeutic strategies being developed for …

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity

C Schmidl, M Klug, TJ Boeld, R Andreesen… - Genome …, 2009 - genome.cshlp.org
DNA methylation participates in establishing and maintaining chromatin structures and
regulates gene transcription during mammalian development and cellular differentiation …

Epigenetics: poly (ADP‐ribosyl) ation of PARP‐1 regulates genomic methylation patterns

P Caiafa, T Guastafierro, M Zampieri - The FASEB Journal, 2009 - Wiley Online Library
In the postgenome era, attention is being focused on those epigenetic modifications that
modulate chromatin structure to guarantee that information present on DNA is read correctly …

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells

J Xu, JA Watts, SD Pope, P Gadue… - Genes & …, 2009 - genesdev.cshlp.org
We reported previously that well-characterized enhancers but not promoters for typical
tissue-specific genes, including the classic Alb1 gene, contain unmethylated CpG …

Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance

EE Bram, M Stark, S Raz, YG Assaraf - Neoplasia, 2009 - Elsevier
ABCG2 is an efflux transporter conferring multidrug resistance (MDR) on cancer cells.
However, the initial molecular events leading to its up-regulation in MDR tumor cells are …

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

N Leuenberger, S Pradervand… - The Journal of clinical …, 2009 - Am Soc Clin Investig
As most metabolic studies are conducted in male animals, understanding the sex specificity
of the underlying molecular pathways has been broadly neglected; for example, whether …