Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Foxp3, a winged-helix family transcription factor, serves as the master switch for CD4+
regulatory T cells (Treg). We identified a unique and evolutionarily conserved CpG-rich …

CpG island–like sequences are commonly thought to provide the sole signals for
designating constitutively unmethylated regions in the genome, thus generating open …

Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and
expansion and forms the basis for novel anabolic therapeutic strategies being developed for …

DNA methylation participates in establishing and maintaining chromatin structures and
regulates gene transcription during mammalian development and cellular differentiation …

In the postgenome era, attention is being focused on those epigenetic modifications that
modulate chromatin structure to guarantee that information present on DNA is read correctly …

We reported previously that well-characterized enhancers but not promoters for typical
tissue-specific genes, including the classic Alb1 gene, contain unmethylated CpG …

ABCG2 is an efflux transporter conferring multidrug resistance (MDR) on cancer cells.
However, the initial molecular events leading to its up-regulation in MDR tumor cells are …

As most metabolic studies are conducted in male animals, understanding the sex specificity
of the underlying molecular pathways has been broadly neglected; for example, whether …