Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy

M Nazıroğlu - Neurochemical research, 2009 - Springer
Epilepsy is one of the oldest neurological conditions known to humankind. It is known that
oxidative stress and generation of reactive oxygen species are a cause and consequence of …

Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid

ÍMS Santos, AR Tome, GB Saldanha… - Oxidative medicine …, 2009 - Wiley Online Library
Ascorbic acid has many nonenzymatic actions and is a powerful water‐soluble antioxidant. It
protects low density lipoproteins from oxidation and reduces harmful oxidants in the central …

Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine

RM Freitas - Neuroscience letters, 2009 - Elsevier
The relationship between free radical and scavenger enzymes has been found in the
epileptic phenomena and reactive oxygen species have been implicated in seizure-induced …

The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures

RM Freitas - Neuroscience letters, 2009 - Elsevier
It has been suggested that pilocarpine-induced seizures is mediated by increases in
oxidative stress. Current researches have suggested that antioxidant compounds may afford …

Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures

EA Wilhelm, CR Jesse, CF Bortolatto, CW Nogueira… - Brain research …, 2009 - Elsevier
This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on
pilocarpine (PC)-, pentylenetetrazole (PTZ)-and kainic acid (KA)-induced seizures and …

Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy

U Yiş, E Seçkin, SH Kurul, F Kuralay, E Dirik - Epilepsy Research, 2009 - Elsevier
The aim of this study is to evaluate the erythrocyte lipid peroxidation and antioxidant enzyme
levels in patients with newly diagnosed idiopathic epilepsy before treatment and in patients …

Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice

C Wakade, MD King, MD Laird… - Antioxidants & redox …, 2009 - liebertpub.com
Cerebral vasospasm is a major cause of death and disability after subarachnoid
hemorrhage (SAH); however, clinical therapies to limit the development of cerebral …

Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum

HVN Júnior, MMF Fonteles… - … medicine and cellular …, 2009 - Wiley Online Library
Previous experiments have shown that the generation of free radicals in rat brain
homogenates is increased following pilocarpine‐induced seizures and status epilepticus …

Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy

S Peternel, K Pilipović, G Župan - Progress in Neuro-Psychopharmacology …, 2009 - Elsevier
Several studies have shown the existence of sex differences in the sensitivity to various
convulsants in animals and to the development of some epilepsy types in humans. The …

NAP prevents hippocampal oxidative damage in neonatal rats subjected to hypoxia-induced seizures

S Greggio, RM Rosa, A Dolganov, IM de Oliveira… - Neurobiology of …, 2009 - Elsevier
Neonatal seizures in which hypoxic-ischemic encephalopathy is the main triggering etiology
have a challenging diagnosis and limited efficacy of treatment. NAP (NAPVSIPQ) has shown …