Immunologic aspects of chronic obstructive pulmonary disease

MG Cosio, M Saetta, A Agusti - New England Journal of Medicine, 2009 - Mass Medical Soc
This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

MR Edwards, NW Bartlett, D Clarke, M Birrell… - Pharmacology & …, 2009 - Elsevier
Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …

Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management

JA Barberà, I Blanco - Drugs, 2009 - Springer
Pulmonary hypertension (PH) is an important complication in the natural history of chronic
obstructive pulmonary disease (COPD). Its presence is associated with reduced survival and …

Lung Myeloid Dendritic Cells Coordinately Induce TH1 and TH17 Responses in Human Emphysema

M Shan, HF Cheng, L Song, L Roberts… - Science translational …, 2009 - science.org
Exposure to tobacco smoke activates innate and adaptive immune responses that in long-
term smokers have been linked to diseases of the lungs, cardiovascular system, joints, and …

Acute and short-term effects of secondhand smoke on lung function and cytokine production

AD Flouris, GS Metsios, AE Carrillo… - American journal of …, 2009 - atsjournals.org
Rationale: The acute effect of secondhand smoke (SHS) on lung function and the duration of
system disruption remain unknown. Objectives: To assess the SHS effects and their duration …

Increased T-regulatory cells within lymphocyte follicles in moderate COPD

J Plumb, LJC Smyth, HR Adams… - European …, 2009 - Eur Respiratory Soc
Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive
pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in …

Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease

MT Borchers, SC Wesselkamper… - The Journal of …, 2009 - Am Soc Clin Investig
Chronic obstructive pulmonary disease (COPD) is a lethal progressive lung disease
culminating in permanent airway obstruction and alveolar enlargement. Previous studies …

Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation

E Mortaz, AD Kraneveld, JJ Smit, M Kool… - PLoS one, 2009 - journals.plos.org
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway
inflammation. Cigarette smoke has been considered a major player in the pathogenesis of …

Артериальная гипертония и хроническая обструктивная болезнь легких: клинико-патогенетические параллели и возможности терапии

ВС Задионченко, ТВ Адашева… - Российский …, 2009 - cyberleninka.ru
По мнению большинства исследователей, и мы поддерживает эту точку зрения,
основным механизмом артериальной гипертонии на фоне ХОБЛ, как системной, так и …

A hypothesis for the initiation of COPD

EG Tzortzaki, NM Siafakas - European Respiratory Journal, 2009 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is generally thought to depend on an
aberrant immune response to a noxious or infectious agent, which may cause chronic …