The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of
normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic …

Reactive oxygen species (ROS) have been suggested to be involved in a variety of human
diseases. Catalase, an enzyme degrading hydrogen peroxide, can be used as a therapeutic …

The mouse model of liver ischemia and reperfusion injury has proven to be valuable for our
understanding of the role that reactive oxygen and nitrogen metabolites play in postischemic …

Ischemia and reperfusion lead to injury of the liver. Ischemia‐reperfusion injury is inevitable
in liver transplantation and trauma and, to a great extent, in liver resection. This article gives …

Helper T cells are known to mediate hepatic ischemia/reperfusion (I/R) injury. However, the
precise mechanisms and subsets of CD4+ T cells that contribute to this injury are still …

Hemoglobin vesicles (HbVs) are artificial oxygen (O 2) carriers that encapsulate
concentrated hemoglobin (Hb) solution in phospholipid vesicles (liposomes). Recent reports …

BACKGROUND/AIMS: Our previous work suggested an important role for the peptidyl-prolyl
isomerase, Pin1, in hepatic NF-κB activation and liver injury during ischemia/reperfusion …

BACKGROUND: Hepatic ischemia/reperfusion (I/R) injury is a principal consideration of
trauma, resectional liver surgery, and transplantation. Despite improvements in supportive …

Hepatic ischemia/reperfusion (I/R) leads to liver injury and dysfunction through the initiation
of a biphasic inflammatory response that is regulated by the transcription factor nuclear …