Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

The outer monolayer of the outer membrane of Gram-negative bacteria consists of the lipid A
component of lipopolysaccharide (LPS), a glucosamine-based saccharolipid that is …

Signal transduction following binding of lipopolysaccharide (LPS) to Toll‐like receptor 4
(TLR4) is an essential aspect of host innate immune responses to infection by Gram …

Escherichia coli mutants deficient in 2-keto-3-deoxy-d-manno-octulosonic acid (Kdo)
biosynthesis are conditionally lethal, but their phenotypes are bypassed by certain …

Francisella tularensis is a highly infectious pathogen that causes tularemia. Francisella lipid
A contains an unusual galactosamine (GalN) unit, attached to its 1-phosphate moiety. Two …

Lipid A of Francisella tularensis subsp. novicida contains a galactosamine (GalN) residue
linked to its 1-phosphate group. As shown in the preceding paper, this GalN unit is …

LpxE, a membrane-bound phosphatase found in Rhizobium leguminosarum and some
other Gram-negative bacteria, selectively dephosphorylates the 1-position of lipid A on the …

Two research projects will be presented with the underlining theme of using tandem mass
spectrometry to achieve fundamental and structural information about relevant …