Chemokine receptors have a key role in the pathogenesis of autoimmune diseases,
inflammation and viral infection. However, with the exception of selective CCR5 antagonists …

Background: Chemokines were originally defined as host defense proteins, however, their
biological role goes well beyond this simple description of their function as immune cell …

Purpose: Tumor cell growth and migration can be directly regulated by chemokines. In the
present study, the association of CCL11 with ovarian cancer has been investigated …

Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …

Background and purpose: In several previous studies, the C‐X‐C chemokine receptor
(CXCR) 2 antagonist 1‐(2‐bromo‐phenyl)‐3‐(7‐cyano‐3H‐benzotriazol‐4‐yl)‐urea …

Drugs can initiate, inhibit, modulate, or potentiate basal activity in cells to produce
physiological effects. The interplay between the fundamental affinity and efficacy of drugs …

In spite of many promising experimental studies, an effective treatment dramatically
eliminating the secondary damage after spinal cord injury (SCI) is still missing. Since clinical …

Chemokine receptor antagonists that held much promise for the treatment of autoimmune
and inflammatory diseases have recently performed poorly in clinical trials, resulting in …

Background: Since the mid-1990s, there has been significant effort invested in the discovery
and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential …

Truncated chemokines lacking an N-terminal region that acti vate CCR1 and/or FPRL1 and
compositions containing the truncated chemokines are provided. Methods of identifying …