Antibiotics are among the most successful drugs used for human therapy. However, since
they can challenge microbial populations, they must be considered as important pollutants …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Multidrug efflux pumps have emerged as relevant elements in the intrinsic and acquired
antibiotic resistance of bacterial pathogens. In contrast with other antibiotic resistance genes …

Azithromycin (AZM) has shown promising results in the treatment of Pseudomonas
aeruginosa chronic lung infections such as those occurring in cystic fibrosis (CF) patients …

Abstract The LysR-family regulator MexT modulates the expression of the MexEF-OprN
efflux system in the human pathogen Pseudomonas aeruginosa. Recently, we demonstrated …

In the human pathogen Pseudomonas aeruginosa, the LysR-family regulator MexT
modulates the induction of the tripartite MexEF-OprN resistance nodulation-division multi …

ExsA is a transcriptional activator of the Pseudomonas aeruginosa type III secretion system
(T3SS). The T3SS consists of> 40 genes organized within 10 transcriptional units, each of …

Stenotrophomonas maltophilia is an opportunistic pathogen characterized for its intrinsic low
susceptibility to several antibiotics. Part of this low susceptibility relies on the expression of …

The intrinsic resistance of P. aeruginosa PAO1 to the peptide deformylase inhibitor (PDF-I)
LBM415 was mediated by the MexAB-OprM and MexXY-OprM efflux pumps, the latter of …

OBJECTIVES: To describe the incidence and clinical characteristics of imipenem-resistant
(IR) Pseudomonas aeruginosa bacteraemia. METHODS: We performed a retrospective …