Mucus production is a primary defense mechanism for maintaining lung health. However,
the overproduction of mucin (the chief glycoprotein component of mucus) is a common …

The airways form conduits to allow ambient air to reach alveoli in terminal airways, where
gas exchange occurs, followed by elimination of exchanged air. Although apparently simple …

Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF).
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by …

Human conducting airways contain two anatomically distinct epithelial cell compartments:
surface epithelium and submucosal glands (SMG). Surface epithelial cells interface directly …

Lubiprostone, a putative ClC-2 chloride channel opener, has been investigated for its effects
on airway epithelia (tracheas). Lubiprostone is shown to increase submucosal gland …

F508del is the most common cystic fibrosis-causing mutation that induces early degradation
and poor trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) chloride …

Adenosine (Ado) regulates diverse cellular functions in the lung through its local production,
release, metabolism, and subsequent stimulation of G-protein-coupled P1 purinergic …

Cystic Fibrosis (CF) is a still life-treathening disease, although therapies have augmented
the life span of CF individuals. Isolation of the CF gene, named CFTR (CF Transmembrane …

Formation of multiple-protein macromolecular complexes at specialized subcellular
microdomains increases the specificity and efficiency of signaling in cells. In this study, we …

F508del is the most common cystic fibrosis causing mutation inducing early degradation and
poor trafficking of CFTR chloride channels to the apical membrane of epithelial cells. Our …