Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen
overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most …

Macrophages function as control switches of the immune system, providing a balance
between pro-and anti-inflammatory responses. To accomplish this, they develop into …

Acute liver failure (ALF) remains a disease with poor patient outcome. Improved prognosis is
associated with spontaneous liver regeneration, which supports the relevance of exploring …

CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through
the Nrf2–Keap1 pathway, an important mechanism for the induction of cytoprotective genes …

AIM: To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with
cytochrome P450 (CYP450) expression in mice. METHODS: Hepatic CYP450 and CYPb 5 …

AIM: To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of
Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the …

Oxidant stress is critically involved in various liver diseases. Superoxide formation causes c-
Jun NH2-terminal kinase (JNK)-and caspase-dependent apoptosis in cultured hepatocytes …

Drug-induced liver injury has been associated with the generation of reactive metabolites,
which are primarily detoxified via glutathione conjugation. In this study, it was hypothesized …

(AAP) toxicity in cultured rat hepatocytes. We used different concentrations of AAP–1, 2.5, 5,
10 and 20 mM, to test influence of AAP on cellular viability, functional capacity and oxidative …

Background Many bedridden patients develop pressure ulcers, not only in hospital but also
at home. Clinical studies have indicated cigarette smoking to be a risk factor for pressure …