Mouse models of Huntington disease: variations on a theme
DE Ehrnhoefer, SL Butland… - Disease models & …, 2009 - journals.biologists.com
An accepted prerequisite for clinical trials of a compound in humans is the successful
alleviation of the disease in animal models. For some diseases, however, successful …
alleviation of the disease in animal models. For some diseases, however, successful …
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Huntingtin is phosphorylated on serine-421 (S421) by the pro-survival signaling protein
kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable in different regions of …
kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable in different regions of …
Huntington's disease–new perspectives based on neuroendocrine changes in rodent models
Å Petersén, S Hult, D Kirik - Neurodegenerative Diseases, 2009 - karger.com
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
repeat in the huntingtin gene. Although it is characterized by progressive motor impairments …
repeat in the huntingtin gene. Although it is characterized by progressive motor impairments …
BAC to Degeneration: Bacterial Artificial Chromosome (BAC)-Mediated Transgenesis for Modeling Basal Ganglia Neurodegenerative Disorders
XH Lu - International review of neurobiology, 2009 - Elsevier
Basal ganglia neurodegenerative disorders, such as Parkinson's disease (PD) and
Huntington's disease (HD), are characterized by not only spectrum of motor deficits, ranging …
Huntington's disease (HD), are characterized by not only spectrum of motor deficits, ranging …
Murine models of Huntington disease
A Sturrock, BR Leavitt - Future Neurology, 2009 - Taylor & Francis
Huntington disease is an inherited neurodegenerative disorder associated with inexorable
progression. To date, no therapy has proved effective in modifying the disease course or …
progression. To date, no therapy has proved effective in modifying the disease course or …
A neuroanatomical analysis of striosome-matrix compartmentalization and motor deficits in YAC mouse models of Huntington's disease
C Lawhorn - 2009 - repository.yu.edu
The striatum contains mu opioid receptor-rich (MOR) cells called striosomes embedded in
an extrastriosomal matrix. In Huntington's disease (HD), the striosomes and matrix may be …
an extrastriosomal matrix. In Huntington's disease (HD), the striosomes and matrix may be …
Analyse der N-terminalen proteolytischen Prozessierung von Huntingtin
K Jünemann - 2009 - db-thueringen.de
Analyse der N-terminalen proteolytischen Prozessierung von Huntingtin – Digitale
Bibliothek Thüringen Toggle navigation Suche einfacherweitert Blättern EinrichtungenDokumenttypenSachgruppenPersonen …
Bibliothek Thüringen Toggle navigation Suche einfacherweitert Blättern EinrichtungenDokumenttypenSachgruppenPersonen …
[引用][C] Modelos animales de enfermedades neurodegenerativas: ejemplo de la enfermedad de Huntington
JJL Lozano, ZO Llorente - Avances en neurociencia …, 2009 - dialnet.unirioja.es