Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

Studies on the increasing number of transporters found in the placental barrier are gaining
momentum, because of their tissue‐specific expression, significance in physiology and …

Recent progress in basic research has enhanced our understanding of the molecular
mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter …

Drug-induced liver injury (DILI) is an increasing health problem and a challenge for
physicians, regulatory bodies and the pharmaceutical industry, not only because of its …

Pharmacokinetic limitations affect drug bioavailability determining the loss or the reduction
of the pharmacological effects. The Gastro Intestinal tract (GI) and the Blood Brain Barrier …

Like most drugs, macrocyclic lactone endectocides (MLs) exert their antiparasitic effects
within the defined target tissues where parasites are located, and whose drug …

Primary malignancies of the liver and the gastrointestinal tract constitute one of the main
health problems worldwide. Together, these types of tumour are the first cause of death due …

AZD1152 is a highly selective Aurora B kinase inhibitor currently undergoing Phase I and II
clinical evaluation in patients with acute myelogenous leukemia and advanced solid …

Background The choroid plexus consists of highly differentiated epithelium and functions as
a barrier at the interface of the blood-cerebrospinal-fluid (CSF). This tissue may therefore …