Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis
The study of biomarkers and their signalling pathways has allowed the development of new
therapeutic strategies in a range of disorders. The aim of the present systematic review is to …
therapeutic strategies in a range of disorders. The aim of the present systematic review is to …
Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological …
L Elia, R Contu, M Quintavalle, F Varrone, C Chimenti… - Circulation, 2009 - Am Heart Assoc
Background—MicroRNAs (miRNAs/miRs) are small conserved RNA molecules of 22
nucleotides that negatively modulate gene expression primarily through base paring to the …
nucleotides that negatively modulate gene expression primarily through base paring to the …
The insulin-like growth factor family: molecular mechanisms, redox regulation, and clinical implications
G Vardatsikos, A Sahu, AK Srivastava - Antioxidants & redox …, 2009 - liebertpub.com
Insulin-like growth factor (IGF)-induced signaling networks are vital in modulating multiple
fundamental cellular processes, such as cell growth, survival, proliferation, and …
fundamental cellular processes, such as cell growth, survival, proliferation, and …
Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction
Administration of mesenchymal stem cells (MSCs) is an effective therapy to repair cardiac
damage after myocardial infarction (MI) in experimental models. However, the mechanisms …
damage after myocardial infarction (MI) in experimental models. However, the mechanisms …
[HTML][HTML] IGF-1 Expression in Infarcted Myocardium and MGF E Peptide Actions in Rat Cardiomyocytes in Vitro
A Stavropoulou, A Halapas, A Sourla, A Philippou… - Molecular …, 2009 - Springer
Abstract Insulinlike growth factor-1 (IGF-1) expression is implicated in myocardial
pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF …
pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF …
Role of obesity in cardiomyopathy and pulmonary hypertension
CSD Cruz, RA Matthay - Clinics in chest medicine, 2009 - Elsevier
Obesity is becoming a worldwide problem of epidemic proportions, and its effect on the heart
is increasingly being recognized. Obesity is often associated with an increased risk for heart …
is increasingly being recognized. Obesity is often associated with an increased risk for heart …
Cardiac-specific overexpression of insulin-like growth factor I (IGF-1) rescues lipopolysaccharide-induced cardiac dysfunction and activation of stress signaling in …
Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria,
plays a key role in cardiac dysfunction in sepsis. Low circulating levels of insulin-like growth …
plays a key role in cardiac dysfunction in sepsis. Low circulating levels of insulin-like growth …
[PDF][PDF] Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Gaq signaling
RJ Chen, HC Wu, MH Chang, CH Lai, YC Tien… - J Mol Endocrinol, 2009 - Citeseer
This study examines the role of IGF2/mannose 6-phosphate receptor (IGF2R) signaling in
the signaling transduction regulation and cell apoptosis in H9c2 cardiomyoblast cells …
the signaling transduction regulation and cell apoptosis in H9c2 cardiomyoblast cells …
[HTML][HTML] Serum IGF-I and hormonal responses to incremental exercise in athletes with and without left ventricular hypertrophy
A Żebrowska, Z Gąsior, J Langfort - Journal of Sports Science & …, 2009 - ncbi.nlm.nih.gov
We investigated the response of insulin-like growth factor (IGF-I), insulin-like growth factor
binding protein-3 (IGFBP-3) and some hormones, ie, testosterone (T), growth hormone (GH) …
binding protein-3 (IGFBP-3) and some hormones, ie, testosterone (T), growth hormone (GH) …
[PDF][PDF] Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta …
CH Chu, CY Huang, MC Lu, JA Lin, FJ Tsai, CH Tsai… - Chin J Physiol, 2009 - cps.org.tw
Our previous studies found that insulin-like growth factor-I receptor (IGF1R) signaling
blockade caused cardiac hypertrophy, and that apoptosis is required for upregulating the …
blockade caused cardiac hypertrophy, and that apoptosis is required for upregulating the …