Hemostasis and pathological thrombus formation are dynamic processes that require a co-
ordinated series of events involving platelet membrane receptors, bidirectional intracellular …

Tissue factor (TF) is a member of the cytokine receptor superfamily and binds FVII/VIIa. The
TF: FVIIa complex has both procoagulant and signaling activities. It functions in many …

Tissue factor (TF) is an integral membrane protein, normally separated from the blood by the
vascular endothelium, which plays a key role in the initiation of blood coagulation. With a …

Background: Tissue factor (TF) is present in blood in various forms, including small
membrane vesicles called microparticles (MPs). Elevated levels of these MPs appear to play …

Microvesicles comprised of exosomes and microparticles are shed from both normal and
malignant cells upon cell activation or apoptosis. Microvesicles promote clot formation …

Tissue factor (TF) initiates coagulation, regulates hemostasis, and plays a critical role in
mediating arterial thrombosis. TF is up-regulated in vascular smooth muscle cells (VSMCs) …

Objectives–To review the role of thrombin in physiology and clinical disease and to discuss
the pharmacology of antithrombosis. Data Sources–Original research articles, scientific …

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) patients have increased
risk for cardiovascular mortality and venous thromboembolism. Tissue factor (TF) is the …

Individuals whose platelets lack dense or α-granules suffer various degrees of abnormal
bleeding, implying that granule cargo contributes to hemostasis. Despite these clinical …

The hemostatic process is a host defense mechanism to preserve the integrity of the closed
high pressure circulatory system. This process must remain inactive but poised to minimize …